If you have a wound on your skin then will recover you will feel itch. The wound would heal will create a new skin growth that will close the wound and form a granules network (cell growth) that many exert of histamine substance. This substance will causes feel itch. More wide of the wound then will feel more itchy. Anti-histamine medicine will reduce of this itchiness.
Thus this histamine substance causes itchiness in the new growth skin. Compound other than histamine may arise because on our body metabolism, this substance can also come from other sources such as tuna fish or a person who allergic to certain food types, so that the body naturally create histamine to fight foreign substances, and this histamine causing itchiness.
Therefore, to reduce the itchiness can use anti-histamine drugs that will react with the histamine substances and form a new neutral compound does not cause itchiness on our skin. Because histamine is polar substances so can dissolve in water and alcohol.
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